唐勇

作者：来源：发布日期：2023-03-17 浏览次数：

唐勇.jpg

唐勇，男，304永利集团官网入口教授,博士生导师，国家级领军人才。具二十多年分子生物学、动物胚胎及全能干细胞、基因工程、抗病毒研究和药物研发的经验。研究方向涵盖胚胎干细胞介导的优良家畜育种及家畜医学模型，以及全能干细胞介导的家畜新型抗病毒药物研发。

一、教育经历：

2007/9-2012/5

[美国] 康涅狄格大学, 动物科学系, 博士

1993/9-1996/7

湖南医科大学, 医学遗传学系, 硕士

1988/9-1993/7

湖南医科大学, 临床医学系, 学士

二、工作经历：

2022/11-至今:

304永利集团官网入口, 304永利集团官网入口, 基础医学系，教授

2020/9-2022/8 :

[美国] 康涅狄格大学, 动物科学系, 终身副教授

2014/9-2020/8

[美国] 康涅狄格大学, 动物科学系, 助理教授

2012/6-2014/8

[美国] 康涅狄格大学, 动物科学系, 博士后

2002/5-2007/8

[美国] 波士顿千禧年制药公司, 高级研究助理、研究员

1999/8-2002/4

[美国] 中佛罗里达大学, 研究助理

1997/9-1999/7

[德国] 埃兰根-纽伦堡大学, 访问学者

三、代表性论文（^†通讯作者）

· Zhu J, He X, Bernard D, Shen J, Su Y, Molek A, Issacs B, Mishra N, TianX.C., Garmendia A, Tang, Y^†. (2023). Identification of New Compounds against PRRSV Infection by Directly Targeting CD163. Journal of Virology. 2023 May 3;e0005423. doi: 10.1128/jvi.00054-23. (Editor’s Pick). Online ahead of print.

· Zhu J, Su Y, Tang, Y^†. (2022). Disrupting ACE2 Dimerization Mitigates the Infection by SARS-CoV-2 Pseudovirus. Front. Virol ., 04 July 2022 Sec. Antivirals and Vaccines https://doi.org/10.3389/fviro.2022.916700.

· Su Y, Wang L, Fan Z, Liu Y, Zhu J, Kaback D, Oudiz J, Patrick T, Yee S.P, Tian X.C, Polejaeva I, Tang Y^†. (2021). Establishment of Bovine-Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 22(19), 10489; https://doi.org/10.3390/ijms221910489.

· Su Y, Zhu J, Salman S, Tang Y^†. (2020). The Induced Pluripotent Stem Cells from Farm Animals. Journal of Animal Science . https://doi.org/10.1093/jas/skaa343.

· Huang C, Zhu J, Wang L, Chu A, Yin Y, Vali K, Garmendia A, Tang Y^†. (2020). Cryptotanshinone Protects Porcine Alveolar Macrophages from Infection of Porcine Reproductive and Respiratory Syndrome Virus. Antiviral Research. DOI: 10.1016/j.antiviral.2020.104937.

· Huang C, Bernard D, Zhu J, Dash RC, Chu A, Knupp A, Hakey A, Hadden MK, Garmendia, A, Tang Y^†. (2020). Small Molecules Block Porcine Reproductive and Respiratory Syndrome Virus Interaction with CD163 and Infection of Pig Cells. BMC Virology Journal . DOI: 10.1186/s12985-020-01361-7.

· Wang L, Su Y, Huang C, Yin Y, Zhu J, Knupp A, Chu A, Tang Y^†. (2019). FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming. Scientific Reports. 9:16443 | https://doi.org/10.1038/s41598-019-52861-8.

· Huang D, Wang L, Talbot NC, Huang C, Pu L, Zhao X, Tian X, Zhang M, Tang Y^†. (2018). Analyzing Bovine OCT4 and NANOG Enhancer Activity in Pluripotent Stem Cells Using Fluorescent Protein Reporters. PLoS ONE . 5;13(10):e0203923. https://doi.org/10.1371/journal.pone.0203923

· Wang L, Jiang Z, Huang D, Duan J, Huang C, Sullivan S, Vali K, Yin Y, Zhang M, Wegrzyn J, Tian XC, Tang Y^†. (2018). Jak/Stat3 Regulated Global Gene Expression Dynamics During Late-Stage Reprogramming Process. BMC Genomics. 6;19(1):183. DOI: 10.1186/s12864-018-4507-2

· Wang L, Huang D*, Huang C*, Yin Y, Vali K, Zhang M, Tang Y^†. (2017).

Enhanced Human Somatic Cell Reprogramming Efficiency by Fusion of the MYC Transactivation Domain and OCT4. Stem Cell Research . 25: 88-97. https://doi.org/10.1016/j.scr.2017.10.014

· Jiang Z, Tang Y, Zhao X, Zhang M, Donovan DM, Tian XC. (2015). Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells. Stem Cells & Dev . 24(19):2328-36. 2015 Oct 1;24(19):2328-36. doi: 10.1089/scd.2015.0069.

· Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC. (2014). Differential Effects of Akt Isoforms on Somatic Cell Reprogramming. J. Cell Sci . 2014 Sep 15;127(Pt 18):3998-4008. doi: 10.1242/jcs.150029.

· Tang Y and Tian XC. (2013). Jak/Stat3 and Somatic Cell Reprogramming. JAK-STAT . 2:e24935; http://dx.doi.org/10.4161/jkst.24935 (Invited Review)

· Tang Y, Luo Y, Jiang Z, Ma Y, Lin CJ, Kim C, Carter MG, Amano T, Park J, Kish S, and Tian XC. (2012). Jak/Stat3 Signaling Promotes Complete Reprogramming by Epigenetic Regulation. Stem Cells . 2012, Sep 11. https://doi.org/10.1002/stem.1225

· Tang Y, Lin CJ, and Tian XC. (2011). Functionality and Transduction Condition Evaluation of Recombinant Klf4 for Improved Reprogramming of iPS Cells. Cellular Reprogram. Apr;13(2):99-112. DOI: 10.1089/cell.2010.0072

· Fernandez-Valle C, Tang Y, Ricard J, Rodenas-Ruano A, Taylor A, Hackler E, Biggerstaff J & Lacovelli J. (2002). Paxillin Binds Schwannomin and Regulates Its Density-Dependent Localization and Effect on Cell Morphology. Nature Genetics . Aug;31(4):354-62. DOI: 10.1038/ng930

· Schmucker B, Tang Y, and Kressel M. (1999). Novel Alternatively Spliced Isoforms of the Neurofibromatosis Type 2 Tumor Suppressor Are Targeted to the Nucleus and Cytoplasmic Granules. Hum. Mol. Genet . Aug; 8(8): 1561-70. DOI: 10.1093/hmg/8.8.1561